I live in Deshaies, and it's pretty safe (crime wise), but the roads are quite poorly lit and windy, so wear bright colours/bring reflective armbands/torches. I don't know that much about accomodation, but it's quite a touristy place so I think there are lots of options. I didn't have a car for my first two weeks and I always walked to and from town (I live quite close to the botanical gardens, 2km away from the town).
Hope this helps a bit!